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RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
TCIM
RNA ID
RNA Type
mRNA
Alteration Pattern
dna hypermethylation
Species
homo sapiens
Detection Methods
qRT-PCR; Immunohistochemistry; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis
Year
2016
Function
"Decreased capacity of fibrotic lung fibroblasts to up-regulate COX-2 expression and COX-2-derived PGE2 synthesis is due to an indirect epigenetic mechanism involving hypermethylation of the transcriptional regulator, c8orf4."